Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial.
Identifieur interne : 001A51 ( Main/Exploration ); précédent : 001A50; suivant : 001A52Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial.
Auteurs : Dinesh Khanna [États-Unis] ; Christopher P. Denton [Royaume-Uni] ; Angelika Jahreis [États-Unis] ; Jacob M. Van Laar [Pays-Bas] ; Tracy M. Frech [États-Unis] ; Marina E. Anderson [Royaume-Uni] ; Murray Baron [Canada] ; Lorinda Chung [États-Unis] ; Gerhard Fierlbeck [Allemagne] ; Santhanam Lakshminarayanan [États-Unis] ; Yannick Allanore [France] ; Janet E. Pope [Canada] ; Gabriela Riemekasten [Allemagne] ; Virginia Steen [États-Unis] ; Ulf Müller-Ladner [Allemagne] ; Robert Lafyatis [États-Unis] ; Giuseppina Stifano [États-Unis] ; Helen Spotswood [Royaume-Uni] ; Haiyin Chen-Harris [États-Unis] ; Sebastian Dziadek [Suisse] ; Alyssa Morimoto [États-Unis] ; Thierry Sornasse [États-Unis] ; Jeffrey Siegel [États-Unis] ; Daniel E. Furst [États-Unis]Source :
- Lancet (London, England) [ 1474-547X ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Anticorps monoclonaux humanisés (administration et posologie), Anticorps monoclonaux humanisés (usage thérapeutique), Canada, Capacité vitale, Europe, Femelle, Humains, Injections sous-cutanées, Interleukine-6 (physiologie), Marqueurs biologiques (métabolisme), Mâle, Méthode en double aveugle, Royaume-Uni, Résultat thérapeutique, Sclérodermie systémique (), Sclérodermie systémique (métabolisme), Sclérodermie systémique (traitement médicamenteux), Sujet âgé.
- MESH :
- administration et posologie : Anticorps monoclonaux humanisés.
- métabolisme : Marqueurs biologiques, Sclérodermie systémique.
- physiologie : Interleukine-6.
- traitement médicamenteux : Sclérodermie systémique.
- usage thérapeutique : Anticorps monoclonaux humanisés.
- Adulte, Adulte d'âge moyen, Canada, Capacité vitale, Europe, Femelle, Humains, Injections sous-cutanées, Mâle, Méthode en double aveugle, Royaume-Uni, Résultat thérapeutique, Sclérodermie systémique, Sujet âgé.
English descriptors
- KwdEn :
- Adult, Aged, Antibodies, Monoclonal, Humanized (administration & dosage), Antibodies, Monoclonal, Humanized (therapeutic use), Biomarkers (metabolism), Canada, Double-Blind Method, Europe, Female, Humans, Injections, Subcutaneous, Interleukin-6 (physiology), Male, Middle Aged, Scleroderma, Systemic (complications), Scleroderma, Systemic (drug therapy), Scleroderma, Systemic (metabolism), Treatment Outcome, United Kingdom, Vital Capacity.
- MESH :
- chemical , administration & dosage : Antibodies, Monoclonal, Humanized.
- chemical , metabolism : Biomarkers.
- chemical , physiology : Interleukin-6.
- chemical , therapeutic use : Antibodies, Monoclonal, Humanized.
- complications : Scleroderma, Systemic.
- drug therapy : Scleroderma, Systemic.
- metabolism : Scleroderma, Systemic.
- Adult, Aged, Canada, Double-Blind Method, Europe, Female, Humans, Injections, Subcutaneous, Male, Middle Aged, Treatment Outcome, United Kingdom, Vital Capacity.
Abstract
Systemic sclerosis is a rare disabling autoimmune disease with few treatment options. The efficacy and safety of tocilizumab, an interleukin 6 receptor-α inhibitor, was assessed in the faSScinate phase 2 trial in patients with systemic sclerosis.
DOI: 10.1016/S0140-6736(16)00232-4
PubMed: 27156934
Affiliations:
- Allemagne, Canada, France, Pays-Bas, Royaume-Uni, Suisse, États-Unis
- Angleterre, Bade-Wurtemberg, Berlin, Californie, Connecticut, District de Columbia, District de Tübingen, Grand Londres, Massachusetts, Michigan, Utah, Utrecht (province), Île-de-France
- Berlin, Londres, Paris, Tübingen, Utrecht
- University College de Londres
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Le document en format XML
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Nauheim</wicri:noRegion></affiliation></author><author><name sortKey="Lafyatis, Robert" sort="Lafyatis, Robert" uniqKey="Lafyatis R" first="Robert" last="Lafyatis">Robert Lafyatis</name><affiliation wicri:level="2"><nlm:affiliation>Boston University School of Medicine, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Boston University School of Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Stifano, Giuseppina" sort="Stifano, Giuseppina" uniqKey="Stifano G" first="Giuseppina" last="Stifano">Giuseppina Stifano</name><affiliation wicri:level="2"><nlm:affiliation>Boston University School of Medicine, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Boston University School of Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Spotswood, Helen" sort="Spotswood, Helen" uniqKey="Spotswood H" first="Helen" last="Spotswood">Helen Spotswood</name><affiliation wicri:level="1"><nlm:affiliation>Roche Products, Welwyn Garden City, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Roche Products, Welwyn Garden City</wicri:regionArea><wicri:noRegion>Welwyn Garden City</wicri:noRegion></affiliation></author><author><name sortKey="Chen Harris, Haiyin" sort="Chen Harris, Haiyin" uniqKey="Chen Harris H" first="Haiyin" last="Chen-Harris">Haiyin Chen-Harris</name><affiliation wicri:level="2"><nlm:affiliation>Genentech, South San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genentech, South San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Dziadek, 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Electronic address: khannad@med.umich.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Michigan Scleroderma Program, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Denton, Christopher P" sort="Denton, Christopher P" uniqKey="Denton C" first="Christopher P" last="Denton">Christopher P. Denton</name><affiliation wicri:level="4"><nlm:affiliation>University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Jahreis, Angelika" sort="Jahreis, Angelika" uniqKey="Jahreis A" first="Angelika" last="Jahreis">Angelika Jahreis</name><affiliation wicri:level="2"><nlm:affiliation>Genentech, South San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genentech, South San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Van Laar, Jacob M" sort="Van Laar, Jacob M" uniqKey="Van Laar J" first="Jacob M" last="Van Laar">Jacob M. Van Laar</name><affiliation wicri:level="3"><nlm:affiliation>University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Frech, Tracy M" sort="Frech, Tracy M" uniqKey="Frech T" first="Tracy M" last="Frech">Tracy M. Frech</name><affiliation wicri:level="2"><nlm:affiliation>University of Utah, Veterans Affairs Medical Center, Salt Lake City, UT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Utah, Veterans Affairs Medical Center, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Anderson, Marina E" sort="Anderson, Marina E" uniqKey="Anderson M" first="Marina E" last="Anderson">Marina E. Anderson</name><affiliation wicri:level="1"><nlm:affiliation>University of Liverpool and Aintree University Hospital, Liverpool, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Liverpool and Aintree University Hospital, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Baron, Murray" sort="Baron, Murray" uniqKey="Baron M" first="Murray" last="Baron">Murray Baron</name><affiliation wicri:level="1"><nlm:affiliation>Jewish General Hospital, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Jewish General Hospital, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Chung, Lorinda" sort="Chung, Lorinda" uniqKey="Chung L" first="Lorinda" last="Chung">Lorinda Chung</name><affiliation wicri:level="2"><nlm:affiliation>Stanford University School of Medicine and Palo Alto VA Health Care System, Palo Alto, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford University School of Medicine and Palo Alto VA Health Care System, Palo Alto, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Fierlbeck, Gerhard" sort="Fierlbeck, Gerhard" uniqKey="Fierlbeck G" first="Gerhard" last="Fierlbeck">Gerhard Fierlbeck</name><affiliation wicri:level="3"><nlm:affiliation>University of Tübingen, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tübingen, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Lakshminarayanan, Santhanam" sort="Lakshminarayanan, Santhanam" uniqKey="Lakshminarayanan S" first="Santhanam" last="Lakshminarayanan">Santhanam Lakshminarayanan</name><affiliation wicri:level="2"><nlm:affiliation>University of Connecticut Health Center, Farmington, CT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Connecticut Health Center, Farmington, CT</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Allanore, Yannick" sort="Allanore, Yannick" uniqKey="Allanore Y" first="Yannick" last="Allanore">Yannick Allanore</name><affiliation wicri:level="3"><nlm:affiliation>Paris Descartes University and Cochin Hospital, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Paris Descartes University and Cochin Hospital, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Pope, Janet E" sort="Pope, Janet E" uniqKey="Pope J" first="Janet E" last="Pope">Janet E. Pope</name><affiliation wicri:level="1"><nlm:affiliation>Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Riemekasten, Gabriela" sort="Riemekasten, Gabriela" uniqKey="Riemekasten G" first="Gabriela" last="Riemekasten">Gabriela Riemekasten</name><affiliation wicri:level="3"><nlm:affiliation>Charité University Hospital, German Rheumatism Research Centre, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Charité University Hospital, German Rheumatism Research Centre, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Steen, Virginia" sort="Steen, Virginia" uniqKey="Steen V" first="Virginia" last="Steen">Virginia Steen</name><affiliation wicri:level="2"><nlm:affiliation>Georgetown University, Washington, DC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Georgetown University, Washington, DC</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Muller Ladner, Ulf" sort="Muller Ladner, Ulf" uniqKey="Muller Ladner U" first="Ulf" last="Müller-Ladner">Ulf Müller-Ladner</name><affiliation wicri:level="1"><nlm:affiliation>Justus-Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Justus-Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim</wicri:regionArea><wicri:noRegion>Bad Nauheim</wicri:noRegion><wicri:noRegion>Bad Nauheim</wicri:noRegion><wicri:noRegion>Bad Nauheim</wicri:noRegion></affiliation></author><author><name sortKey="Lafyatis, Robert" sort="Lafyatis, Robert" uniqKey="Lafyatis R" first="Robert" last="Lafyatis">Robert Lafyatis</name><affiliation wicri:level="2"><nlm:affiliation>Boston University School of Medicine, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Boston University School of Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Stifano, Giuseppina" sort="Stifano, Giuseppina" uniqKey="Stifano G" first="Giuseppina" last="Stifano">Giuseppina Stifano</name><affiliation wicri:level="2"><nlm:affiliation>Boston University School of Medicine, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Boston University School of Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Spotswood, Helen" sort="Spotswood, Helen" uniqKey="Spotswood H" first="Helen" last="Spotswood">Helen Spotswood</name><affiliation wicri:level="1"><nlm:affiliation>Roche Products, Welwyn Garden City, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Roche Products, Welwyn Garden City</wicri:regionArea><wicri:noRegion>Welwyn Garden City</wicri:noRegion></affiliation></author><author><name sortKey="Chen Harris, Haiyin" sort="Chen Harris, Haiyin" uniqKey="Chen Harris H" first="Haiyin" last="Chen-Harris">Haiyin Chen-Harris</name><affiliation wicri:level="2"><nlm:affiliation>Genentech, South San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genentech, South San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Dziadek, Sebastian" sort="Dziadek, Sebastian" uniqKey="Dziadek S" first="Sebastian" last="Dziadek">Sebastian Dziadek</name><affiliation wicri:level="1"><nlm:affiliation>Roche, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Roche, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Morimoto, Alyssa" sort="Morimoto, Alyssa" uniqKey="Morimoto A" first="Alyssa" last="Morimoto">Alyssa Morimoto</name><affiliation wicri:level="2"><nlm:affiliation>Genentech, South San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genentech, South San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Sornasse, Thierry" sort="Sornasse, Thierry" uniqKey="Sornasse T" first="Thierry" last="Sornasse">Thierry Sornasse</name><affiliation wicri:level="2"><nlm:affiliation>Genentech, South San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genentech, South San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Siegel, Jeffrey" sort="Siegel, Jeffrey" uniqKey="Siegel J" first="Jeffrey" last="Siegel">Jeffrey Siegel</name><affiliation wicri:level="2"><nlm:affiliation>Genentech, South San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genentech, South San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Furst, Daniel E" sort="Furst, Daniel E" uniqKey="Furst D" first="Daniel E" last="Furst">Daniel E. Furst</name><affiliation wicri:level="2"><nlm:affiliation>University of California, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Antibodies, Monoclonal, Humanized (administration & dosage)</term><term>Antibodies, Monoclonal, Humanized (therapeutic use)</term><term>Biomarkers (metabolism)</term><term>Canada</term><term>Double-Blind Method</term><term>Europe</term><term>Female</term><term>Humans</term><term>Injections, Subcutaneous</term><term>Interleukin-6 (physiology)</term><term>Male</term><term>Middle Aged</term><term>Scleroderma, Systemic (complications)</term><term>Scleroderma, Systemic (drug therapy)</term><term>Scleroderma, Systemic (metabolism)</term><term>Treatment Outcome</term><term>United Kingdom</term><term>Vital Capacity</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anticorps monoclonaux humanisés (administration et posologie)</term><term>Anticorps monoclonaux humanisés (usage thérapeutique)</term><term>Canada</term><term>Capacité vitale</term><term>Europe</term><term>Femelle</term><term>Humains</term><term>Injections sous-cutanées</term><term>Interleukine-6 (physiologie)</term><term>Marqueurs biologiques (métabolisme)</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Royaume-Uni</term><term>Résultat thérapeutique</term><term>Sclérodermie systémique ()</term><term>Sclérodermie systémique (métabolisme)</term><term>Sclérodermie systémique (traitement médicamenteux)</term><term>Sujet âgé</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Interleukin-6</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Scleroderma, Systemic</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Scleroderma, Systemic</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Scleroderma, Systemic</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Marqueurs biologiques</term><term>Sclérodermie systémique</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Interleukine-6</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Sclérodermie systémique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Canada</term><term>Double-Blind Method</term><term>Europe</term><term>Female</term><term>Humans</term><term>Injections, Subcutaneous</term><term>Male</term><term>Middle Aged</term><term>Treatment Outcome</term><term>United Kingdom</term><term>Vital Capacity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Canada</term><term>Capacité vitale</term><term>Europe</term><term>Femelle</term><term>Humains</term><term>Injections sous-cutanées</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Royaume-Uni</term><term>Résultat thérapeutique</term><term>Sclérodermie systémique</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Systemic sclerosis is a rare disabling autoimmune disease with few treatment options. The efficacy and safety of tocilizumab, an interleukin 6 receptor-α inhibitor, was assessed in the faSScinate phase 2 trial in patients with systemic sclerosis.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>France</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Bade-Wurtemberg</li><li>Berlin</li><li>Californie</li><li>Connecticut</li><li>District de Columbia</li><li>District de Tübingen</li><li>Grand Londres</li><li>Massachusetts</li><li>Michigan</li><li>Utah</li><li>Utrecht (province)</li><li>Île-de-France</li></region><settlement><li>Berlin</li><li>Londres</li><li>Paris</li><li>Tübingen</li><li>Utrecht</li></settlement><orgName><li>University College de Londres</li></orgName></list><tree><country name="États-Unis"><region name="Michigan"><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name></region><name sortKey="Chen Harris, Haiyin" sort="Chen Harris, Haiyin" uniqKey="Chen Harris H" first="Haiyin" last="Chen-Harris">Haiyin Chen-Harris</name><name sortKey="Chung, Lorinda" sort="Chung, Lorinda" uniqKey="Chung L" first="Lorinda" last="Chung">Lorinda Chung</name><name sortKey="Frech, Tracy M" sort="Frech, Tracy M" uniqKey="Frech T" first="Tracy M" last="Frech">Tracy M. Frech</name><name sortKey="Furst, Daniel E" sort="Furst, Daniel E" uniqKey="Furst D" first="Daniel E" last="Furst">Daniel E. Furst</name><name sortKey="Jahreis, Angelika" sort="Jahreis, Angelika" uniqKey="Jahreis A" first="Angelika" last="Jahreis">Angelika Jahreis</name><name sortKey="Lafyatis, Robert" sort="Lafyatis, Robert" uniqKey="Lafyatis R" first="Robert" last="Lafyatis">Robert Lafyatis</name><name sortKey="Lakshminarayanan, Santhanam" sort="Lakshminarayanan, Santhanam" uniqKey="Lakshminarayanan S" first="Santhanam" last="Lakshminarayanan">Santhanam Lakshminarayanan</name><name sortKey="Morimoto, Alyssa" sort="Morimoto, Alyssa" uniqKey="Morimoto A" first="Alyssa" last="Morimoto">Alyssa Morimoto</name><name sortKey="Siegel, Jeffrey" sort="Siegel, Jeffrey" uniqKey="Siegel J" first="Jeffrey" last="Siegel">Jeffrey Siegel</name><name sortKey="Sornasse, Thierry" sort="Sornasse, Thierry" uniqKey="Sornasse T" first="Thierry" last="Sornasse">Thierry Sornasse</name><name sortKey="Steen, Virginia" sort="Steen, Virginia" uniqKey="Steen V" first="Virginia" last="Steen">Virginia Steen</name><name sortKey="Stifano, Giuseppina" sort="Stifano, Giuseppina" uniqKey="Stifano G" first="Giuseppina" last="Stifano">Giuseppina Stifano</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Denton, Christopher P" sort="Denton, Christopher P" uniqKey="Denton C" first="Christopher P" last="Denton">Christopher P. Denton</name></region><name sortKey="Anderson, Marina E" sort="Anderson, Marina E" uniqKey="Anderson M" first="Marina E" last="Anderson">Marina E. Anderson</name><name sortKey="Spotswood, Helen" sort="Spotswood, Helen" uniqKey="Spotswood H" first="Helen" last="Spotswood">Helen Spotswood</name></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Van Laar, Jacob M" sort="Van Laar, Jacob M" uniqKey="Van Laar J" first="Jacob M" last="Van Laar">Jacob M. Van Laar</name></region></country><country name="Canada"><noRegion><name sortKey="Baron, Murray" sort="Baron, Murray" uniqKey="Baron M" first="Murray" last="Baron">Murray Baron</name></noRegion><name sortKey="Pope, Janet E" sort="Pope, Janet E" uniqKey="Pope J" first="Janet E" last="Pope">Janet E. Pope</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Fierlbeck, Gerhard" sort="Fierlbeck, Gerhard" uniqKey="Fierlbeck G" first="Gerhard" last="Fierlbeck">Gerhard Fierlbeck</name></region><name sortKey="Muller Ladner, Ulf" sort="Muller Ladner, Ulf" uniqKey="Muller Ladner U" first="Ulf" last="Müller-Ladner">Ulf Müller-Ladner</name><name sortKey="Riemekasten, Gabriela" sort="Riemekasten, Gabriela" uniqKey="Riemekasten G" first="Gabriela" last="Riemekasten">Gabriela Riemekasten</name></country><country name="France"><region name="Île-de-France"><name sortKey="Allanore, Yannick" sort="Allanore, Yannick" uniqKey="Allanore Y" first="Yannick" last="Allanore">Yannick Allanore</name></region></country><country name="Suisse"><noRegion><name sortKey="Dziadek, Sebastian" sort="Dziadek, Sebastian" uniqKey="Dziadek S" first="Sebastian" last="Dziadek">Sebastian Dziadek</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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